Middlesex County is a county located on the Middle Peninsula in the U.S. state of Virginia. As of the 2020 census, the population was 10,625. Its county seat is Saluda.

Cities: Urbanna
Founded: 1673
Population: 10,943 (2022)
Area: 211 mi²
County seat: Saluda
Congressional district: 1st
Named for: Middlesex, England